Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis

Cristina Lorenzini
Cristina Lorenzini
Matthew Meyer
Matthew Meyer
Ryosuke Saigusa
Ryosuke Saigusa
Zhichao Fan
Zhichao Fan
Nadine Hartmann
Nadine Hartmann
Jennifer M Dan
Jennifer M Dan
Gregory J Golden
Gregory J Golden
Rajee Ganesan
Rajee Ganesan

The Journal of experimental medicine, 2021.

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Abstract:

Rolling neutrophils form tethers with submicron diameters. Here, we report that these tethers detach, forming elongated neutrophil-derived structures (ENDS) in the vessel lumen. We studied ENDS formation in mice and humans in vitro and in vivo. ENDS do not contain mitochondria, endoplasmic reticulum, or DNA, but are enriched for S100A8, S...More

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