β-Caryophyllene exerts protective antioxidant effects through the activation of NQO1 in the MPTP model of Parkinson’s disease

•Interest in how β-Caryophyllene to prevent pro oxidation environment in the Parkinson’s disease.•β-Caryophyllene active the NQO1 pathway in neurodegenerative model.•Cannabinoid type 2-receptor agonists exerts protective antioxidant effects through NQO1 pathway.•Hypothesis: β-Caryophyllene inhibits oxidative stress-induced cell death of dopaminergic neurons exposed to MPTP and enhances the expression and enzymatic activity of NQO1.