Effect of Older vs Younger Age on Anthropometric and Metabolic Variables During Treatment of Psychotic Depression With Sertraline Plus Olanzapine: The STOP-PD II Study

•This study examined the effect of older versus younger age on change in anthropometric and metabolic measures during extended treatment of psychotic depression with sertraline plus olanzapine.•Among patients with psychotic depression, acute and stabilization treatment with sertraline plus olanzapine was associated with increase in weight and total cholesterol, but the trajectory of these increases was less in older compared with younger participants. Weight gain in older participants appeared to be restoration of weight lost during the episode of depression, whereas weight gain in younger participants was not.•Older patients with psychotic depression experience less increase in weight and total cholesterol than their younger counterparts during acute and stabilization treatment with sertraline plus olanzapine.