Synthesis of chromene-2-thiones and in vitro evaluation of their antifungal and antibacterial activities

Cyclocondensation of beta-oxodithioesters with substituted 2-hydroxy benzaldehydes in presence of copper(II)chloride as the catalyst yields 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones (87-95% yields). These reactions are carried out under solvent-free conditions. All the synthesized compounds have been evaluated for their antifungal and antibacterial activities using tube dilution technique. Only five compounds are found exhibiting good antifungal and antibacterial activities.