Protective Effects of Radix Ophiopogon Japonicus Extracts on H2O2-induced Damage in HUVECs

X. Zhang, T. L. Lu,J. Fan,X. Y. Zhang,F. R. Jiang, Z. Zhan,J. A. Duan,J. Yang, B. C. Cai

ICCB 2008: PROCEEDINGS OF THE 9TH INTERNATIONAL CONGRESS ON CELL BIOLOGY（2008）

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摘要

Ophiopogonin D and extracts by n-Butanol, water and chloroform were obtained from Radix Ophiopogon Japotticus. Their protective effects on H2O2-induced damage in human umbilical vascular endothelial cells (HUVECs) were observed. All three extractes can decrease the apoptosis of HUVECs, among which n-Butanol extract has strong effect. As the main ingredient, Ophiopogonin D could down regulate the over-expression of KDR, MMP9, RHOB, VCAM1 by H2O2.

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