PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

Gary A. Piazza,Antonio Ward,Xi Chen,Yulia Maxuitenko, Alex Coley,Nada S. Aboelella,Donald J. Buchsbaum, Michael R. Boyd,Adam B. Keeton,Gang Zhou

Drug Discovery Today（2020）

引用 0|浏览2

暂无评分

摘要

•NSAIDs have anticancer activity but have toxicities resulting from COX inhibition.•The mechanism of NSAID anticancer activity may not require COX inhibition.•PDE5 and PDE10 are overexpressed in tumors and essential for cancer cell growth.•Novel sulindac derivatives targeting PDE5 or PDE10 have strong anticancer activity.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要