Therapeutic Activities of IL-12 Gene-Modified Macrophages Embedded in Gelatin Matrix Hemostatic Sealant (FloSeal (R)) in a Mouse Model of Residual Prostate Cancer

Ken-ichi Tabata,Masami Watanabe,Takefumi Satoh,Wei-hau Tian,Hongyu Wang,ElMoataz Abdel Fattah,Guang Yang,Daniel Floryk,Dov Kadmon,Timothy C. Thompson

MOLECULAR THERAPY（2006）

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摘要

INTRODUCTION AND OBJECTIVE: Despite improved surgical techniques local tumor recurrence after radical prostatectomy is not uncommon. We previously reported that IL-12 gene modified macrophages (IL-12/M|[Phi]|) suppress tumor growth and metastasis in pre-clinical mouse models of prostate cancer (Satoh et al, Cancer Res., 63: 7853-7860, 2003).

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