New Pt(II) complexes with 3 ’ -methyl tetrahydro-4 H -thiopyranspiro-5 ’ -hydantoin: synthesis, theoretical and cytotoxic investigation

Three new platinum complexes with chemical formulas cis -[PtL 2 Cl 2 ], cis -[PtL 2 I 2 ] and cis -[PtL(NH 3 )Cl 2 ], where L is 3 ’ -methyl-4-thio-1 H -tetrahydropyranspiro-5 ’ -hydantoin were synthesized and studied. The spectral and theoretical investigations proved that ligand coordinates through sulfur atom from tetrahydrothiopyrane fragment by monodentate manner with platinum ion. The newly synthesized compounds were tested for cytotoxic activity in vitro against four human tumor cell lines using MTT dye-reduction assay for cell viability. The tested compounds displayed cytotoxic effects in a concentration-dependent manner. Complex 2 as well as complex 3 have similar cytotoxicity to that of the prototype drug cisplatin on colon adenocarcinoma model HT-29.