Palladium-Catalyzed C(Sp(3))-H Nitrooxylation With Tert-Butyl Nitrite And Molecular Oxygen

ORGANIC LETTERS(2020)

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摘要
Herein, we report a Pd(II)-catalyzed nitrooxylation of unactivated methyl C(sp(3))-H bonds using commercial available and easily manageable tert-butyl nitrite as the precursor of ONO2 radical under aerobic conditions. Environmentally benign molecular oxygen is used to initiate the generation of active radical reactant; it is also used as the terminal oxidant. A broad range of nitrooxylated aliphatic carboxamides were prepared in moderate to good yields under mild conditions.
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