Differences in Pharmacological Potency Influence Blood Pressure Response to Celecoxib and Naproxen

Katherine N. Theken,Soumita Ghosh,Carsten Skarke,Susanne Fries,Nicholas F. Lahens,Dimitra Sarantopoulou,Gregory R. Grant,Garret A. FitzGerald,Tilo Grosser

CIRCULATION（2019）

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摘要

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of adverse cardiovascular events via suppression of cyclooxygenase (COX)-2-derived prostacyclin (PGI2) formation in he...

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