Synthesis, Crystal Structure and Antibacterial Activity of Ammonium Bromide

The new title compound N-(2-hydroxy ethyl) tetrahydropalmatine ammonium bromide has been synthesized staffing from palmatine hydrochloride. The structure of the product was confirmed by H-1 NMR, MS (ESI) and single-crystal X-ray diffraction. The title compound crystallizes in the triclinic system, space group P (1) over bar with a = 10.5887(11), b = 10.8652(9), c = 12.0914(12) angstrom, beta = 84.808(9)degrees, V = 1253.3(2) angstrom(3), Z = 2, D-c = 1.355 g/cm(3), F(000) = 530, mu = 1.680 mm(-1), the final R = 0.0833 and wR = 0.2371 for 5112 observed reflections (I > 2 sigma(I)). X-ray analysis indicates that the two planar parts (C(2) C(3) C(4) C(5) C(6) C(7) N(1) C(20) C(21) C(21)) and (C(7) C(8) C(9) C(10) C(12) C(14) N(15) C(16) C(17)) are not coplanar, with the dihedral angles to be 67.9 degrees. Weak interactions mainly between O(5)-H(5)center dot center dot center dot O from two water molecules and O(5)center dot center dot center dot Br are observed.