N,N,N ',N '-Tetra-[(diphenylphosphino)methyl]ethylenediamine/Palladium Catalyzed Heck Reaction

The catalytic performance of tetraphosphine based on ethylenediamine as backbone, N,N,N',N'-tetra[(diphenylphosphino)methyl]ethylenediamine, combined with palladium for the Heck reactions of aryl halides with acrylates was investigated. The results showed that the catalytic system is highly efficient for the Heck reaction of activated aryl bromides as well as inactivated aryl bromides. The yield of 96% was obtained with activated 4-bromobenzaldehyde even the molar ratio of substrate to catalyst up to 1000000, and with inactivated 4-bromoanisole or 4-chloronitrobenzene the high conversion was obtained in the presence of 0.1 mol% Pd.