An Easy Access to 4-Trifluoromethylated 7-(4-Substitued-1H-1,2,3-Triazol-1-yl)Pyrimido[1,2-b]Pyridazin-2-One Systems

Ranin Kawtharani,Khalil Cherry,Mirvat Elmasri,Mohamed Abarbri

CHEMISTRYSELECT（2019）

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摘要

Efficient synthesis of 7-(1H-1,2,3-triazol-1-yl)-4-trifluoromethyl-2H-pyrimido[1,2-b]pyridazin-2-ones from 7-chloro-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one by a consecutive SNAr reaction with azide, followed by copper-catalyzed [3+2] cycloaddition is described.

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关键词

Azide,7-Chloro-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one,Click chemistry,SNAr reaction,4-Trifluoromethylated 7-(1H-1,2,3-triazol-1-yl)-2H-pyrimido[1,2-b]pyridazin-2-ones

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