Open Flask, Clean and Practical Protocol for Diastereoselective Syntheses of Oxindole Containing Phosphinoyl Compounds under Catalyst-Free and Solvent-Free Conditions

An open flask, practical C-P bond formation between oxindole containing allyl alcohols and phosphorous surrogates under catalyst-free and solvent-free conditions is described. The C-P bond formation is completely diastereoselective and amenable to a variety of multifunctional allyl alcohols under the reaction conditions employed, providing the desired products in excellent yields.