Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS

Benedicte Jørgenrud,Eline Skadberg,Julio de Carvalho Ponce,Håvard Furuhaugen,Thomas Berg

Journal of Pharmacological and Toxicological Methods（2021）

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摘要

•Quantification of alcohol biomarker PEth 16:0/18:1 and 33 other compounds by LC-MS/MS•First method for quantification of PEth and drugs from several drug classes•Acidic, basic and ampholytic compounds determined by LC-MS/MS•First supported liquid extraction of pregabalin and gabapentin from blood•High throughput sample preparation by 96-well supported liquid extraction

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关键词

LC-MS/MS,alcohol,blood,illegal and medicinal drugs,multi-compound method,96-well supported liquid extraction,phosphatidylethanol,UHPLC,validated method

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