The global prevalence of chronic HBV infection: a systematic review and meta-analyses on 48 years of published data

(anti-HBs isolated). The four HBV DNApositive samples were classified as subgenotype A1 (3/4) and D3 (1/4). The male gender (adjusted OR: 2.65; p = 0.007), age (adjusted OR: 1.07; p = 0.000), previous transfusion (adjusted OR: 2.52; p = 0.025) and greater period of time living in settlements (adjusted OR: 1.10; p = 0.026) were associated with HBV exposure. A total of 181 HBV susceptible individuals received the first vaccine dose, but only 106 (58.6%; 106/ 181) completed vaccination. Of these, it was possible to assess vaccine response in 77 subjects, and 68.8% (53/77) presented protective titers of anti-HBs. Most non-responders to the vaccine were more than 40 years old (23/24, p < 0.001), and 50% (12/24) were smokers (p < 0.009). Nobody was anti-HDV-positive. CONCLUSION: The results of this study demonstrates the need for effective strategies to prevent hepatitis B in the settlement projects subpopulation, emphasizing vaccination against hepatitis.