[STE029 Overcomes EGFR-TKI Resistance in Human Lung Adenocarcinoma].

Lin Huang,Mei Hou,Jiewei Liu,Yang Li,Wang Shen,Qinghua Zhou

JOURNAL OF THORACIC ONCOLOGY（2022）

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摘要

STE029 could sensitize Gefitinib by inhibiting EGFR/PI3K/Akt pathway, blocking the tumor cell cycle and proliferation and inducing apoptosis through caspase-8 and caspase-9 dependent pathway. STE029 deserves further investigations in overcoming EGFR-TKI resistance in lung cancer.

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关键词

Apoptosis,Cell cycle,EGFR-TKI,Lung adenocarcinoma,Resistance,STE029

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