One pot synthesis and fungicidal activity of some bis-(2-arylamino-1,3,4-oxadiazol-5-yl)propane by electrolytic initiated desulfurization of propylenediacylthiosemicarbazone

A facile and efficient route for synthesis of substituted bis-1,3,4-oxadiazoles have been carried out at platinum electrode from electrocyclization of propylenediacylthiosemicarbazone by using LiClO4 as supporting electrolyte in acetonitrile as non-aqueous solvent under controlled potential electrolysis at room temperature. The synthesized compounds were characterized by spectroscopic methods and mechanism was deduced from cyclic voltammetric studies. The fungicidal activities of products (6a-6f) were evaluated against fungal strain Aspergillus flavus and Alternaria solani. Excellent yields with high atom economy, shortest reaction time and easy work-up are attractive features in context to green chemistry.