beta(2) or beta(3) receptor gene polymorphisms and cardiovascular risk

Adrenergic receptors beta(2) and beta(3) are involved in adipose tissue turnover. This study examines the influence of two polymorphisms: the Trp64Arg on ADR beta(3) and the Gln27Glu on ADR beta(2) on the WHR, blood pressure, glycemia, insulin and the lipid profile following a case-control design. Results: All measurements concerning selected characteristics of obese subjects were statistically significant as compared to lean controls. Those obese individuals carrying the Trp64Arg polymorphism showed higher levels of basal insulinemia, while those obese subjects with the Gln27Glu polymorphism had higher WHR and lower HDL-cholesterol levels. Conclusions: Some of the adverse events associated to the X syndrome may depend on the genetic background. Obesity itself should be considered as a major determinant of the observed metabolic disturbances.