Practical Synthesis of High-Performance Amino Tf-Amide Organocatalysts for Asymmetric Aldol Reactions

A type of optically pure secondary-amino aromatic Tf-amide organocatalysts can be easily prepared from commercially available L-hydroxyproline. The chemical behavior of these organocatalysts was investigated by the application to asymmetric aldol reactions. Among these, catalyst 2 a efficiently catalyzed direct asymmetric aldol reactions of cycloalkanones and substituted benzaldehydes, which afforded the corresponding aldol adducts in good yield with good to excellent anti-diastereo and enantioselectivity.