Isolation and Evaluation of Antinociceptive Activity of Sulfur-Containing Iridoid Glucosides from Paederia scandens

Isolate and purify the sulfur-containing iridoid glucosides from Paederia scandens. Three sulfur-containing iridoid glucosides (1-3) were isolated and the structures of them were elucidated as paederosides (1), paederosidic acid (2) and paederosidic acid methyl ester (3) by spectroscopic analysis. The sulfur-containing iridoid glucosides were evaluated on antinociceptive activity in mice using thermal models of nociception. Both paederosidic acid (2, 120 mg/kg. i.g. or 70 mg/kg, i.p.) and paederosidic acid methyl ester (3, 70 mg/kg, i.p.) produced significant inhibitory activity on thermal nociception in the hot plate test. Paederoside (1, 70 mg/kg, i.p.) had not produced significant antinociceptive effects in the hot plate test.