Changes in DNA Methylation Indicate a Role of Oxidative Stress in Marfan Syndrome

Cassandra Malecki,Elizabeth N. Robertson, Kiersten A. Liddy,Alex Sahagian,Yaxin Lu, Murat Kekic,Donna Lai,Brett D. Hambly,Richmond W. Jeremy

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY（2019）

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摘要

Marfan syndrome (MFS) is due to pathogenic variants in fibrillin-1 (FBN1) and has cardiovascular (CV) manifestations including thoracic aortic aneurysm (TAA) and left ventricular (LV) impairment. C...

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