Expression of gamma-Synuclein in Bladder Carcinoma: A Possible Marker for Prognosis

Aim: To investigate if gamma-synuclein (SNCG) could be used as a bladder cancer (BC) marker to predict prognosis of BC. Patients and Methods: Medical records of 140 patients with BC (January, 2006 to December, 2009) were retrospectively reviewed. SNCG expression level was examined by immunohistological staining. The patients' survival rate was calculated by the Kaplan-Meier method. Cox proportional regression model was used to identify independent predictors for BC. Results: Overexpression of SNCG was detected in BC tissues and the expression level of SNCG strongly positively correlated with BC recurrence. However, no correlation was found between SNCG level and tumor stage or survival rate. Conclusion: SNCG is a good marker to predict recurrence of BC, but not a reliable marker for staging or prediction of survival rate.