Inflammatory manifestations in children with chronic granulomatous disease

Myris Satiko Shinzato Tatebe,Mayra de Barros Dorna,Ana Paula Beltran Moschione Castro,Antonio Carlos Pastorino

JOURNAL OF CLINICAL IMMUNOLOGY（2021）

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摘要

Chronic granulomatous disease (CGD) is a human inborn error of immunity caused by defects in the NADPH oxidase, an enzyme complex responsible for reactive oxygen species (ROS) metabolism. It is characterized by impaired microbicidal activity of the phagocytes, predisposing patients to bacterial and fungal infections, mainly pneumonia, abscesses and adenitis .

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关键词

Chronic granulomatous disease,adolescent,child,granuloma,inflammation,primary immunodeficiency

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