Quinoxapeptins: Novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase .1. The producing organism and biological activity

Quinoxapeptin A and B are novel chromodepsipeptides which were isolated from a nocardioform actinomycete with indeterminant morphology. Quinoxapeptins a and B are potent inhibitors of HIV-1 and HIV-2 reverse transcriptase and almost equally active against two single mutants forms as well as a double mutant form of HIV-1 reverse transcriptase. Quinoxapeptin A and B are specific inhibitors of HIV-I and HIV-2 reverse transcriptase because they did not inhibit human DNA polymerase alpha, beta, gamma, and delta. Quinoxapeptin A and B are structurally similar to luzopeptin A which was also active against HIV-land HIV-2 reverse transcriptase.