STUDY DESCRIBING THE FORMULATION AND THE RELEASE OF SOME ACTIVE PHARMACEUTICAL INGREDIENTS FROM HPMC HYDROPHILIC MATRIX TABLETS. NOTE I

For this study, hydroxypropylmethylcellulose (HPMC) matrix tablets were prepared by direct compression containing active pharmaceutical ingredients (APIs) from different biopharmaceutical classification system (BCS) classes, diclofenacum sodium (DicloNa) and phenytoin sodium (PheNa). For each API, three formulations were obtained, varying the amount of API and the concentration of HPMC matrix. After preparation, the tablets were submitted to pharmaco-technical tests and dissolution tests. The dissolution data was then fitted on different release models. Informations about the release kinetics from our tablets were obtained from these fittings.