Palladium-Catalyzed peri-Selective C-H Fluoroalkoxylation of Aryl Sulfoxides

Sulfinyl-directed peri-selective C-H fluoroalkoxylation of aryl sulfoxides with fluorinated alcohols has been developed. By means of a palladium catalyst and PhI(OAc)(2) as an oxidant, a range of fluoroalkoxy groups can be installed onto the peri position of aryl sulfoxides. The remaining sulfinyl groups on the fluoroalkoxylation products further promote Pummerer-based C-H functionalizations.