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Synthesis and Structure-Activity Studies of Novel Anhydrohexitol-Based Leucyl-tRNA Synthetase Inhibitors.

Dries De Ruysscher,Luping Pang,Stijn M. G. Lenders,Davie Cappoen,Paul Cos,Jef Rozenski,Sergei Strelkov,Stephen D. Weeks,Arthur Van Aerschot

European Journal of Medicinal Chemistry（2020）

Cited 16|Views39
Key words
Leucyl-tRNA synthetase,Bi-substrate competitive inhibitors,Protein-ligand co-crystal structures,Structure-activity relationship,Enzyme inhibition
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