Amino acids amides of anti-influenza drugs: synthesis and biological activities

Influenza A viruses are amongst the most severe human pathogens leading to high morbidity and mortality worldwide. Due to the high mutation rate and the unpredictable potential for influenza pandemic outbreaks, the development of novel anti-influenza drugs is an undeniably attractive area of research. In the present study amino acid amides of rimantadine and oseltamivir were synthesized and their in vitro antiviral activity against influenza A viruses (A/H3N2) was studied. Results revealed that amide modification of N-alpha- and side chain protected tyrosine, histidine, aspartic- and glutamic acids did not exhibit significant enhancement of the in vitro effect against influenza A virus strain.