FGFR Regulation of Dendrite Elaboration in Adult-born Granule Cells Depends on Intracellular Mediator and Proximity to the Soma

Neuroscience(2021)

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摘要
•In newborn adult hippocampal neurons, FGFR signaling through FRS is required to promote proximal dendrite length.•In contrast, FGFRs are required to inhibit distal dendrite length through PLCγ in newborn adult hippocampal neurons.•FGFRs through as yet unidentified mediators promote or counterbalance inhibition of dendrite length by FGFR-PLCγ.
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关键词
DCX,DG,FGF-2,FGFRs,FRS,GCs,PLCγ,RGL
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