Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury

Sahil Gupta
Sahil Gupta
Amir K Varkouhi
Amir K Varkouhi
Ana Paula Teixeira Monteiro
Ana Paula Teixeira Monteiro
Xiaolin He
Xiaolin He

Redox biology, pp. 1017962020.

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Keywords:
Acute lung injuryDJ-1PARK7VILI

Abstract:

Oxidative stress is considered one of the early underlying contributors of acute lung injury (ALI) and ventilator-induced lung injury (VILI). DJ-1, also known as PARK7, has a well-established role as an antioxidant. We have previously shown maintaining oxidative balance via the ATF3-Nrf2 axis was important in protection from ALI. Here, we...More

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