Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease

Anna Pensalfini,Seonil Kim,Shivakumar Subbanna,Cynthia Bleiwas,Chris N. Goulbourne,Philip H. Stavrides,Ying Jiang,Ju-Hyun Lee,Sandipkumar Darji,Monika Pawlik,Chunfeng Huo,James Peddy,Martin J. Berg,John F. Smiley,Balapal S. Basavarajappa,Ralph A. Nixon

CELL REPORTS（2020）

引用 65|浏览42

关键词

Alzheimer’s disease,Rab5 hyperactivation,endosomal dysfunction,synaptic deficits,spine loss,aberrant endosomal signaling,cholinergic neurodegeneration,memory impairment,amyloid precursor protein,tau

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