Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.

Somaia Elsheikh, Ilias Kouzoukakis,Catherine Fielden, Wei Li, Shaimaa Elsaid Lashin,Nadia Khair,Teresa Pereira Raposo,Wakkas Fadhil,Philip Rudland,Mohammed Aleskandarany,Poulam Patel,Mohamed El-Tanani,Mohammad Ilyas

Journal of clinical pathology（2020）

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摘要

Ran is a poor prognostic marker in cutaneous MM. It upregulates expression of the oncogene c-Met and, possibly through this, it promotes cell motility which may in turn promote metastasis.

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melanoma,molecular biology,oncogenes,skin neoplasms

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