Circulating tumor DNA in neoadjuvant-treated breast cancer reflects response and survival
Annals of Oncology(2021)
摘要
•Lack of ctDNA clearance early during NAC portends poor response.•Detectable ctDNA during NAC is associated with poor outcomes.•Failure to clear ctDNA after NAC is associated with inferior distant disease-free recurrence survival.•Clearance of ctDNA is associated with improved survival even in patients who did not achieve pCR.
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关键词
breast cancer,circulating tumor DNA,neoadjuvant chemotherapy,pathologic complete response
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