On the particle formation of leucine in spray drying of inhalable microparticles

Mani Ordoubadi,Florence K.A. Gregson,Hui Wang,Mark Nicholas,Sandra Gracin,David Lechuga-Ballesteros,Jonathan P. Reid,Warren H. Finlay,Reinhard Vehring

International Journal of Pharmaceutics（2021）

引用 32|浏览28

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摘要

•Dispersibility enhancing capability of leucine is mostly due to its crystallization.•Other excipients or actives can hinder the crystallization of leucine.•Leucine is expected to undergo spontaneous nucleation at a supersaturation of 3.5.•Polydisperse spray-dried powders might have size-dependent levels of crystallinity.

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关键词

Spray drying,Leucine,Crystallization,Dispersibility enhancers,Particle engineering,Pharmaceutical aerosols,TOF-SIMS

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