Visible-Light-Induced Radical Isocyanide Insertion Protocol For The Synthesis Of Difluoromethylated Spiro[Indole-3,3 '-Quinoline] Derivatives

Herein, we report the first protocol for visible-light-induced radical isocyanide insertion reactions between 3-(2-isocyanobenzyl)-indoles and bromodifluoroacetates or bromodifluoroacetamides. The protocol, which has good functional group tolerance and a broad substrate scope, constitutes an efficient and general route to difluoromethylated spiro[indole-3,3'-quinoline] derivatives.