Role of nano-lipid formulation of CARP-1 mimetic, CFM-4.17 to improve systemic exposure and response in osimertinib resistant non-small cell lung cancer

Nagavendra Kommineni,Ebony Nottingham,Arvind Bagde,Nilkumar Patel,Arun K Rishi,Satyanarayan R S Dev,Mandip Singh

European Journal of Pharmaceutics and Biopharmaceutics（2021）

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摘要

We have successfully formulated CFM 4.17 NLPFs by robust RSM design approach displaying improved response through sensitizing cells to Osimertinib treatment as well as improving the oral bioavailability of CFM 4.17.

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关键词

Nano lipid formulation,Sustained-release,Cancer,Oral bioavailability,Quality by design,Drug resistance

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