Sorting hidden patterns in nanoparticle performance for glioblastoma using machine learning algorithms

João Basso,Maria Mendes,Jessica Silva,Tânia Cova,Edurne Luque-Michel,Andreia F. Jorge,Santiago Grijalvo,Lídia Gonçalves,Ramon Eritja,María J. Blanco-Prieto,António José Almeida,Alberto Pais,Carla Vitorino

International Journal of Pharmaceutics（2021）

引用 5|浏览24

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摘要

•Glycerol-based cationic lipids are proposed as a safer alternative to CTAB.•Machine learning unravels the key factors governing the effectiveness of NLCs.•NLCs were successfully optimized resorting to machine learning algorithms.•The developed NLCs are less cytotoxic and highly internalized by glioblastoma cells.

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关键词

Glycerol-based cationic lipids,Glioblastoma,Machine learning,Nanostructured lipid carriers,Neural networks

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