A Potential Role Of Interleukin 10 In Covid-19 Pathogenesis

Ligong Lu,Hui Zhang,Danielle J Dauphars,You-Wen He

TRENDS IN IMMUNOLOGY（2021）

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摘要

A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL 10 elevation may play a pathological role in COVID-19 severity.

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关键词

COVID-19,IL-10,IL-6,cytokine storm,mortality,pathogenesis,proinflammation

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