Diagnostic Value of Kidney Injury Molecule- 1 in Feline Lower Urinary Tract Disease

This study was carried out to investigate the diagnostic value of kidney injury molecule-1(KIM-1) in feline lower urinary tract disease (FLUTD). Forty seven Persian cats involved in this study divided into control group (9 cats) and FLUTD cases (31 obstructive and 7 non obstructive). Blood serum and urine samples were examined for determination of serum KIM-1, creatinine, BUN, sodium, potassium and urine KIM-1, physical, chemical and microscopical examination. Ultrasonography and histopathology of kidney and bladder were performed. Level of serum KIM-1 in cases of obstructive FLUTD was significantly increased about 20 fold than control group while in non-obstructive cats there was significant 2 fold increase. Kidney injury molecule 1 could be used as early diagnostic and prognostic test in suspected acute kidney injuries.