Histone Deacetylase Activity and the Renin-Angiotensin-Aldosterone System: Key Elements in Cardiorenal Alterations Provoked by Chronic Malnutrition in Male Adult Rats.

Humberto Muzi-Filho,Larissa B Jannuzzi, Ana C S Bouzan, Sarana Alves-Barros, Danilo S Alves-Bezerra,Amaury Pereira-Acácio, Bruna S N Ferreira,Debora Silva-Pereira,Gloria Costa-Sarmento,Adalberto Vieyra

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2020）

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摘要

The HDAC/RAAS axis appears to be a key regulator of Na-transporting ATPases in renal cortex corticis and cardiomyocytes via an appropriate balance of PKC and PKA activities. Modifications within the HDAC/RAAS axis provoked by chronic M - with repercussions in renal and cardiac Na transport - underpin alterations in bodily Na homeostasis that culminate with the onset of arterial hypertension and potential cardiorenal syndrome.

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关键词

Chronic malnutrition, Renin-Angiotensin-Aldosterone System, Histone deacetylases, Arterial hypertension, Signaling pathways

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