Alterations of Brain Networks in Alzheimer’s Disease and Mild Cognitive Impairment: A Resting State fMRI Study Based on a Population-specific Brain Template

Neuroscience(2021)

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摘要
•This is the first functional brain network graph analysis on AD and MCI based on a population-specific Chinese brain atlas.•Assortativity, degree centrality, clustering, nodal and local efficiency of frontal gyrus, cerebellum altered in AD, MCI.•The altered graph metrics of the frontal gyrus may reflect brain plasticity.•Patients with MCI may have unique graph metric alterations in the cerebellum.•Several graph metrics were significantly correlated with cognitive function and the ability of daily living.
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AAL,AD,ADAS-Cog,ADL,ANOVA,CDR,Cerebelum_Crus1_L,Cerebelum_Crus1_R,DICOM,DPARSF,DWI,EPI,FDR,FLAIR,Frontal_Mid_L,Frontal_Sup_Medial_L,GCA,GRAPPA,GRETNA,HAMD,HC,HIS,LTD,LTP,MCI,MMSE,MNI152,MoCA,MPRAGE,MTA,NIA-AA,NIfTI,NPI,rs-fMRI,SMS,SPM,SUVR,SWI,T1WI,T2WI,Vermis_3
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