Molecular Docking Analysis of Chlorogenic Acid Against Matrix Metalloproteinases (MMPs)

Wound healing is one of the most critical and complex processes in the human system which involves many enzymes. Overexpression of Matrix metalloproteinases (MPs) at the wound site delay the wound healing process. These overexpressed MMPs can be down -regulated or inhibited using small bioactive molecules derived from natural sources. Chlorogenic acid is a polyphenol derivative found in coffee and a well-known antioxidant. The main objective of the study is to unveil the molecular mechanism by which chlorogenic acid binds to the MMPs through molecular docking studies. The result of docking studies showed that chlorogcnic acid showed an excellent binding affinity towards all four selected MMPs. The free binding energy of MMPs 2, 3, 8, and 12 were about -9.32, -8.17, -8.85, and -7.431kcal/mol, respectively. Thus chlorogcnic acid can be used to regulate the activity of metalloproteinases and help to promote wound healing activity.