Changes in the prefrontal cortex after the hippocampus was injected with Aβ25-35 via the P35/P25-CDK5-Tau hyperphosphorylation signaling pathway

Yiying Wang,Huajun Sheng, Jing Zhao,Ling Guo,Jianing Liu,Jin Xu,Qian Liu,Juan Huang,Rong Jiang,Shengwei Gan,Guoping Qiu,Weitian Lu,Shiye Xu,Shujuan Zhu

Neuroscience Letters（2021）

引用 1|浏览21

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摘要

•There is evidence of prefrontal abnormalities in Alzheimer’s disease, but the relationship to hippocampal damage is unknown.•Injection of Aβ25−35 into the hippocampi lead to changes in the P35/P25-CDK5 pathway in the prefrontal cortex.•This is one potential mechanism for prefrontal-mediated cognitive impairment and psychiatric symptoms of AD.

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关键词

Alzheimer’s disease,P35/P25-CDK5,Prefrontal cortex,Hippocampus

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