Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions

•Gap junction-mediated inter-neuronal communication is regulated by mGluRs.•mGluRs trigger long-term changes in electrical synaptic transmission.•mGluR actions on electrical synapses might also involve other neurotransmitters.•These interactions play relevant roles during neurodevelopment and brain injury.