Identification of a New Complement Factor H Mutation in a Patient With Pregnancy-Related Acute Kidney Injury

Severe microangiopathic hemolytic anemia and thrombocytopenia during pregnancy or during the postpartum period requires a differential diagnosis between hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, thrombotic thrombocytopenic purpura, and complement-mediated thrombotic microangiopathy. The 3 diseases may merge into one another, overlap syndromes are increasingly described, and the differential diagnosis may sometimes be allowed only by genetic analysis.1,2