Potential inhibitory effect of lycopene on prostate cancer

Mahdi Mirahmadi, Shayan Azimi-Hashemi,Ehsan Saburi,Hossein Kamali, Mandana Pishbin,Farzin Hadizadeh

Biomedicine & Pharmacotherapy（2020）

引用 88|浏览12

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摘要

•Lycopene is a natural, prominent, and effective product.•We have studied about the anti-cancer, anti-progressive and apoptotic effects.•Lycopene suppress the progression and proliferation.•Lycopene arrest in-cell cycle, and induct apoptosis of prostate cancer cells.•Lycopene could modulate the signaling pathways and their protein.

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关键词

GJC,Hl-60,NF-κB,JNK,Nrf2,BDNF,iNOS,COX-2,PGE2,NO,IL-1β,IL-6,TNF-α,ROS,Rb,p53,PrEC,IGF-1,HT-29,MMP-7,GSK-3β,Akt,ERK1/2,PI3K,MAPK,AP-1,PC3,miR,ACTH,BMI,Skp2,PSA,STEAP,BRCA1,BRCA2,CaP,PEC,LNCap,VeCaP,Bax,BCL2,BCO2,PPARγ,LXRα,ABCA1,PC-3MM2,PBH,HRPC,HGPIN,TRAMP,IGFBP-3,uPAR,c-fos

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