Radix Tetrastigma flavonoids inhibit the migration and promote the apoptosis of A549 cells both in vitro and in vivo

•RTF exhibited excellent anti-tumor capacity both in vitro and in vivo.•RTF inhibited the invasion and migration of A549 via facilitating F-actin collapse.•RTF suppressed tumor growth via bax/bcl-2/caspase-9/caspase-3-dependent pathway.•RTF restrained VEGF expression and thereby suppressed angiogenesis in tumor.