Synthesis And Biological Evaluation Of New Curcumin Analogs Inhibiting Osteoclastogenesis

Tomikazu Kawano, Aoi Sugawara, Toshika Ohashi,Satoshi Ogawa, Naomi Goto,Mayumi Nakanishi-Matsui,Satoru Tamura

HETEROCYCLES（2020）

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摘要

A series of curcumin analogs (1-3) were newly designed and synthesized for the development of therapeutic agents for osteoporosis. Among the synthesized compounds, 2,5-substituted conjugated thiophene derivative (la) and the corresponding pyrazine derivative (1e) were shown to be potential leads for the development of anti-osteoclastogenesis agent.

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关键词

Curcumin, Osteoclastogenesis, Thiophene, Pyrazine, Wittig Reaction

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