Supercritical CO2 and subcritical water technologies for the production of bioactive extracts from sardine (Sardina pilchardus) waste

•Fractionation of sardine waste from a canning industry was investigated.•Fish oil rich in omega-3 was obtained by supercritical fluid extraction.•Fish protein hydrolysates were produced by subcritical water hydrolysis.•Physical, biochemical, and bioactive properties of the extracts were studied.•Antiproliferative effect of the extracts against adenocarcinoma cells was tested.